66545 - MOLECULAR ANTHROPOLOGY AND HUMAN BIODIVERSITY

Scheda insegnamento

Anno Accademico 2017/2018

Conoscenze e abilità da conseguire

At the end of the course, the student has the basic knowledge on human evolution and variability at the molecular level. In particular, the student is able to: understand the most importance differences between ape and human genomes; discover, assay and make inferences from the patterns of human genetic variation; use software for population genetics data analysis (Arlequin, R software, ADMIXTURE...); provide a correct interpretation of results.

Programma/Contenuti

Course contents

Prerequisites:  knowledge of basic genetics and molecular biology.

  • Introduction to Human Evolutionary Genetics
  • Aims of Molecular Anthropology
  • Population Genetics; Hardy-Weinberg equilibrium with exercises
  • Microevolution and genetic factors: non random mating, genetic drift, gene flow, mutation, natural selection
  • Uniparental Markers -Mitochondrial DNA and Y chromosome phylogeny
  • Origins of modern humans
  • Geographical distribution of diversity, Out of Africa model and Multiregional model
  • Making inference from diversity (measures of molecular diversity, neutrality test, mismatch distribution, phylogenetic trees)
  • The Genographic Project and the 1K Genome Project
  • Basics of R and application in human population genetics

Testi/Bibliografia

Jobling M.A., Hurles M.E., Tyler-Smith C., Human evolutionary genetics, Garland Science, 2004
Material and tools will be provided as an integration to the information given during the lectures
Scientific articles, reference and tools provided during the course.

Metodi didattici

Lectures, exercises during the course for specific aspects, practicum with R language

Modalità di verifica dell'apprendimento

Final examination will be performed  in two different parts:

1) a written test with 10 questions, one is an exercise of population genetics. Each answer has a value up to 3 scores and in the case of complete answers, the student will achieve the full mark cum Laude. 
2) a problem to solve using R software

Strumenti a supporto della didattica

videoproiettore, pc

Orario di ricevimento

Consulta il sito web di Donata Luiselli

Consulta il sito web di Marco Sazzini